Cristiano Ronaldo is missing the Manchester derby with a hip injury and Raphael Varane and Luke Shaw are both absent with Covid.
United have been dealt a major triple blow in the hours leading up to the derby, with Edinson Cavani also missing having been declared fit by Ralf Rangnick in his press conference on Friday.
From the side that drew with Watford a week ago Harry Maguire is in for Varane and Jadon Sancho has replaced Ronaldo, while Scott McTominay also comes in for Nemanja Matic, who is on the bench.
