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The Guardian - AU
The Guardian - AU
National
Melissa Davey Medical editor

Why are there so many Omicron subvariants and why have BA.4 and BA.5 taken hold?

People wearing masks walk along a street in Melbourne, Australia
People wear face masks in Melbourne’s CBD. The BA.4 and BA.5 subvariants of Omicron are now dominant in Australia and worldwide. Photograph: Asanka Ratnayake/Getty Images

On 28 November, the World Health Organization designated the variant B.1.1.529 a variant of concern, naming it Omicron. By February 2022, it overtook the Delta variant to become the dominant strain circulating in Australia and worldwide.

Since then subvariants of Omicron have emerged, the key ones being BA.1, BA.2, BA.4, and BA.5. Both BA.5 and, to a lesser extent, BA.4, rapidly replaced other Omicron subvariants and are now dominant in Australia and worldwide, causing concerning spikes in hospitalisations and deaths.

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