Whoever succeeds Boris Johnson as Prime Minister has an awful lot of big choices to make. There are tens of ministerial jobs to fill and a cabinet to make up including key jobs including education, housing, Northern Ireland secretaries as well as the Welsh Secretary.
There are still questions remaining about how the leadership battle will play out, in terms of a timetable, and when a new leader will be appointed. There could be a caretaker Prime Minister with talk Dominic Raab could take that role up within hours of the Prime Minister's statement. There are 13 Conservative MPs who represent Wales.
READ MORE: The latest as Boris Johnson set to resign