The Los Angeles Chargers are 7.5-point underdogs to the San Francisco 49ers in Week 10 of the 2022 regular season. The over/under is 45.5 points, per Tipico Sportsbook.
That means oddsmakers are taking bets on whether the two teams will combine to score more than or fewer than 45.5 points.
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My score prediction for the game is a 28-21 win for the 49ers, with a combined total of 49 points. So if I were putting money behind my prediction, I’d bet the over.
As for game picks, analysts favor Kyle Shanahan’s Niners in this primetime showdown.
| Expert | Pick |
| Nate Davis (USA Today) | 49ers |
| Jarrett Bell (USA Today) | 49ers |
| Mike Clay (ESPN) | 49ers |
| Matt Bowen (ESPN) | 49ers |
| Pete Prisco (CBS Sports) | 49ers |
| Bill Bender (Sporting News) | Chargers |
| Gregg Rosenthal (NFL Media) | 49ers |
| Bleacher Report | 49ers |
Sunday’s game will begin at 5:20 p.m. PT and will be televised on NBC.
