Both England and Italy suffered defeats in their opening Six Nations game and both will be hoping for a win here to avoid finishing 5th and 6th respectively as they did in last year's tournament.
However, there is only one expected winner in the fixture in Rome on Sunday with England, as expected, overwhelming favourites against a side who haven't won a Six Nations game since 2015.
However, with England having lost four of their last six games in the championship and with Italy's bold performance against France, an upset could well be on the cards here.