James Horan's side hope to make another final as their last regular league fixture sees them take on Kildare.
Interestingly, the game will be played in Leitrim as Avant Money Páirc Seán Mac Diarmada is the venue.
After a strong start, they have tailed off having lost to All-Ireland champions Tyrone and Kerry in their last two encounters.
Meanwhile Kildare just put a healthy score on Monaghan as they continue to perform decently among the elite since being promoted.
Here are the key bits to know ahead of this afternoon's match:
When is it on and what time will throw-in be at?
It's on today Sunday March 27 and throw-in is set for 1:45 pm.
Mayo's rivals for that league final spot, Armagh, are also in action at the same time as they travel to face old foes Donegal.
Is it on TV and if not, available to stream?
Unfortunately TG4 are showing Monaghan vs Dublin live and their deferred game will be from Division 2.
In addition to that, the game doesn't appear to be offered on GAAGO either.
However, you can keep up to speed with all of the latest scores by visiting Mirror Sport's Division 1 LIVE score updates blog.
What are the latest betting odds?
The Connacht champions are favoured at 1/2 while Kildare are out at 9/4.
You can back a draw at 13/2.
Get the latest sports headlines straight to your inbox by signing up for free email alerts