In a recently taken down blog post on Steam (via Wccftech), Nixxes, the developer behind the PC port of Rachet and Clank: Rift Apart, wrote that because of the recent DirectStorage update, you can play the former PS5 exclusive on a hard drive, albeit at its minimum settings.
When Ratchet and Clank: Rift Apart was initially announced, Insomniac's creative director, Marcus Smith, said that the game's dimensional rift gameplay "would not have been possible without the solid-state drive of the PlayStation 5."