Chelsea boss Thomas Tuchel is set to be without one of his most in-form players for the FA Cup trip to Turf Moor.
Moroccan winger Hakim Ziyech remains restricted to the sidelines having missed out on the Carabao Cup final at Wembley Stadium.
Having recently embarked on a sparkling run of form for the Blues - arguably the most eye-catching of his Chelsea career so far - he will certainly be a big miss for Tuchel as his side head to Kenilworth Road.
With that being said, football.london takes a look at three options that Chelsea could potentially call upon as the Blues as they attempt to plot a route through to the quarter-finals of the FA Cup.
Christian Pulisic
The obvious choice to replace Ziyech on Wednesday would be American wideman Christian Pulisic.
Ever since arriving at Stamford Bridge from Borussia Dortmund, he has struggled to string together a consistent run of games in the starting line-up.
A perfect opportunity could be set to come against the Hatters though and should he start, the 23-year-old will no doubt be keen to add to the four goals he has scored in all competitions so far this season.
Romelu Lukaku
One man who will also be anxious to end a recent barren run is club record signing Romelu Lukau.
The Belgian frontman has not yet managed to hit hot form since his return from Inter Milan. He has netted ten goals in all competitions - including during the third round FA Cup clash against Chesterfield Town.
Lukaku also started in the previous round against Plymouth so having started on the bench in the Carabao Cup final, he might well be a good bet to be named in Tuchel’s starting line-up this time around.
Who are the teams you love to hate? Which teams do you have a soft spot for? Take part in our League of Love & Hate survey
Timo Werner
Whilst Lukaku is enduring a frustrating period at the current time, the same could certainly be said of his attacking colleague Timo Werner.
The German has only netted on six occasions so far this season - with his last goal coming in the 5-1 thumping of Chesterfield back at the start of January.
Like Lukaku, he also had to make do with a place on the bench at Wembley so could be called into the starting line-up at Kenilworth Road.