The Special Operations Teams (SOT) of Malkajgiri zone, along with the Keesara police, seized 430 kilograms of dry ganja.
Officials said while three men were caught transporting the contraband from Odisha to Hyderabad in a tempo, the main organisers who were piloting the consignment in a car fled.
The accused were identified as Mohan Rathod, 25, Pedda Babu Rao, 30, and Maddela Ramesh, 27, said the police, adding that the main organiser Bahulya Leelavathi alias Bheem Rao, along with his aides Gopal and Santosh, are at large.