With the holders defeated, a different team will get to lift the Anglo Celt Cup at the end of the month and the first of the Ulster Senior Football Championship semi-finals takes place this Sunday.
Tyrone were beaten by Derry last Sunday in Omagh in a stunning upset with the Oak Leaf County winning 1-18 to 0-10.
The two teams who preceded the Red Hands as provincial champions meet in Clones as 2020 winners Cavan take on 2019 champions Donegal.
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The Breffnimen lost out to Donegal in 2019, but claimed a shock win over Declan Bonner’s men in the Athletic Grounds in 2020.
On Saturday evening, Munster kingpins Cork and Kerry clash at Páirc Uí Rinn after the game was moved out of Páirc Uí Chaoimh as the pitch wouldn’t be ready in time after the stadium hosted two Ed Sheeran concerts last week.
In Connacht, Galway will be strongly fancied to reach the provincial final at the expense of Leitrim when the sides meet at Pearse Stadium on Sunday.
The two U20 All-Ireland semi-finals are also this weekend with Kildare and Sligo clashing on Saturday at Kingspan Breffni Park while Tyrone and Kerry meet at Portlaoise on Sunday. Both games will be televised live on TG4.
In Ulster, there are also four games in the Minor Football Championship on Saturday while several northern counties facing crucial battles in the Christy Ring, Nickey Rackard and Lory Meagher Cups.
Sunday’s live hurling game features All-Ireland champions Limerick at home to an injury-plagued Tipperary side.
Saturday
Electric Ireland Ulster Minor Football Championship round two
Derry v Donegal (Owenbeg, 2pm)
Antrim v Tyrone (Corrigan Park, 2pm)
Electric Ireland Ulster Minor Football Championship round two Qualifiers
Fermanagh v Cavan (Brewster Park, 2pm)
Down v Monaghan (Newry, 2pm)
EirGrid All-Ireland U20 Football Championship semi-final
Kildare v Sligo (Kingspan Breffni Park, 4pm, live on TG4)
Munster Senior Football Championship semi-final
Cork v Kerry (Páirc Uí Rinn, 6pm, live on Sky Sports Arena)
Christy Ring Cup round four
Wicklow v Kildare (Aughrim, 1pm)
Mayo v Sligo (Ballina, 2pm)
Nickey Rackard Cup round four
Roscommon v Tyrone (Dr Hyde Park 2pm)
Armagh v Fermanagh (Crossmaglen, 2pm)
Warwickshire v Donegal (Páirc na hÉireann, 2pm)
Lory Meagher Cup round four
Monaghan v Longford (Inniskeen 2pm)
Louth v Cavan (Darver, 3pm)
Sunday
Christy Ring Cup round four
London v Derry (Owenbeg, 12pm)
Lory Meagher Cup round four
Lancashire v Leitrim (O’Toole’s, Dublin, 12.30pm)
EirGrid All-Ireland U20 Football Championship semi-final
Kerry v Tyrone (Portlaoise, 1pm, Live on TG4)
Ulster Ladies Senior Football Championship semi-final
Cavan v Donegal (Clones, 1.45pm)a
Munster Senior Hurling Championship round three
Limerick v Tipperary (TUS Gaelic Grounds, 2pm, live on RTÉ2)
Connacht Senior Football Championship semi-final
Galway v Leitrim (Pearse Stadium, 3.30pm)
Ulster Senior Football Championship semi-final
Cavan v Donegal (Clones, 4pm, live on RTÉ2 and BBC2)
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