The San Francisco 49ers have not played an international game since their dominant 2013 win over the Jacksonville Jaguars at Wembley. That will change on Monday, but the makeup of the team and the location will be markedly different.
Nine years ago, it was Colin Kaepernick, Frank Gore and Patrick Willis helping inspire the Niners to a 42-10 win in a season that would end in San Francisco progressing to a third successive NFC Championship Game.
No players from that team remain on the roster and, rather than being tasked with excelling in London in late October as that 49ers team did, San Francisco will have to contend with the balmier climate and altitude of Mexico City as they face NFC West rivals the Arizona Cardinals at Estadio Azteca in the final international game of 2022.
