Magnesium supplements have become increasingly popular for everything from muscle cramps and better sleep to migraine prevention and heart health. While magnesium is an essential mineral that plays a role in hundreds of biochemical processes, taking it alongside certain medications or supplements can reduce how well either product works or even increase the risk of side effects. Many of these interactions happen quietly, with no immediate warning signs, making them easy to overlook. Before adding magnesium to your daily routine, here are five potential interactions that you should be aware of.