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Benzinga
Benzinga
Technology
Vandana Singh

Synaffix, MacroGenics Ink Pact For Next Generation Antibody-Drug Conjugates

Synaffix BV has entered into a technology agreement with MacroGenics Inc (NASDAQ:MGNX).

  • Under the licensing agreement, MacroGenics will access Synaffix's clinical-stage GlycoConnect antibody conjugation technology, HydraSpace polar spacer technology, and select toxSYN linker-payloads.
  • These will be combined with MacroGenics' proprietary antibody and bispecific DART antibody platform technologies to generate next-generation antibody-drug conjugates (ADCs).
  • Under the terms of the agreement, Synaffix will be eligible to receive up to $586 million in payments spanning upfront and milestone payments across three programs plus royalties on commercial sales. 
  • The license rights of MacroGenics for each program will be designated as exclusive or non-exclusive to each program's antibody target (or to the combination of two targets, if bispecific). 
  • The first program will commence at the signature, with the option to expand the collaboration to a further two programs by March 2023.
  • Price Action: MGNX shares are down 1.75% at $11.21 during the market session on the last check Thursday.
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