Exeter Chiefs centre Henry Slade is the latest big name player forced to withdraw from England's 36-man Nations squad just six days out from the opening game of the 2023 tournament.
Slade suffered a hip injury in Exeter Chief’s game against Castres in the Heineken Champions before last week’s training camp, and has not recovered sufficiently to be available for selection.
Slade, 29, missed England's summer tour of Australia after having surgery on his shoulder but returned in the Autumn Nations series to play all four internationals as he earned his 52nd cap for his country.