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Andrew Yockey, Assistant Professor of Public Health, University of Mississippi

Speedballing – the deadly mix of stimulants and opioids – requires a new approach to prevention and treatment

Speedballing kills nearly 35,000 people in the U.S. every year. Cappi Thompson/Moment via Getty Images

Speedballing – the practice of combining a stimulant like cocaine or methamphetamine with an opioid such as heroin or fentanyl – has evolved from a niche subculture to a widespread public health crisis. The practice stems from the early 1900s when World War I soldiers were often treated with a combination of cocaine and morphine.

Once associated with high-profile figures like John Belushi, River Phoenix and Chris Farley , this dangerous polysubstance use has become a leading cause of overdose deaths across the United States since the early- to mid-2010s.

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