
Speedballing – the practice of combining a stimulant like cocaine or methamphetamine with an opioid such as heroin or fentanyl – has evolved from a niche subculture to a widespread public health crisis. The practice stems from the early 1900s when World War I soldiers were often treated with a combination of cocaine and morphine.
Once associated with high-profile figures like John Belushi, River Phoenix and Chris Farley , this dangerous polysubstance use has become a leading cause of overdose deaths across the United States since the early- to mid-2010s.