Mikel Arteta saw his Arsenal side on the receiving end of a defeat for just the third time this season after goals from former Gunner Danny Welbeck, Kaoru Mitoma and Tariq Lamptey ended the Gunners three-game winning run without conceding.
Bukayo Saka was left out of the squad after featuring in all of Arsenal's games this season but Gabriel Martinelli and Granit Xhaka were both included in the squad and introduced in the second half as the Gunners sought to get back into the game.
Many of Arsenal's players have learnt their World Cup fate over the last few days with Xhaka, William Saliba and Matt Turner all heading to Qatar with Switzerland, France and USA respectively and will certainly be hoping they avoid any injuries before the competition begins on November 20.