Chelsea have made £175million from selling academy players since July 2015, the highest of any Premier League side and 21% of the total earned from transfers by the club.
The figures come from the latest CIES' Football Observatory weekly post and name striker Tammy Abraham, who last summer moved to Roma, as the most profitable sale.
On the flip side the West London club have four current players who were the highest academy sales from their previous clubs: Ben Chilwell of Leicester City, Kai Havertz of Bayer Leverkusen, Kepa Arrizabalaga of Athletic Club and Christian Pulisic of Borussia Dortmund.
CIES' list ranks the top 50 clubs worldwide to have "generated the most incomes since July 2015 from the transfer of players [who] graduated from their youth academy and having been at the club for at least three years between the seasons of their 15th and 21st birthday."
While Chelsea are the highest ranked among Premier League clubs in eighth overall they are followed by Liverpool in 10th on £142.4million, accounting for 41% of their total market income. Arsenal sit 19th overall with Tottenham Hotspur in 31st. Both Manchester clubs, Leicester and Aston Villa are also listed.
Benfica tops the table with £316million made, Real Madrid are second with £274million, Monaco third on £237.4million and Ajax just behind having banked £235.7million. The highest non-European team is Brazilian club Flamengo in 13th on £126.6million.
The Football Observatory said: "With €2.03billion (£1.69million), English clubs generated the most money by the transfer of academy graduates since July 2015, just ahead of French teams (€1.61billion).
"Spanish clubs (€1.39billion) complete the podium per nation, ahead of the Italians (€1.11billion), the Brazilians (€951million), the Germans (€916million), the Portuguese (€788million), the Dutch (€709million) and the Argentineans (€566million)."
You can read more from the CIES Football Observatory here.
