Robert Peston accidentally dropped the C-bomb while referring to Jeremy Hunt live on air last night.
The ITV political editor made the blunder as he discussed the new chancellor's planned cuts to public spending.
Speaking on his Wednesday evening show, he said: "That means the hole in the public finances is bigger than it would have been, and Jeremy c***'s - Hunt's - cuts will be more painful."
Social media users quickly picked up on the error, with one tweeting: "Never a good idea to use the name Jeremy Hunt and the word cuts in the same sentence."
Another joked: "Never gets boring."
A third wrote: "Scripting 'Hunt’s cuts' is just asking for trouble."
And a fourth questioned: ""How does this keep happening?"
The slip-up came as Channel 4 presenter Krishnan Guru-Murthy was caught on camera calling Steve Baker a "c***" outside 10 Downing Street.
He could be heard making the slur before laughing in a clip that has been widely shared on social media.
Minister for Northern Ireland Mr Baker has since called for the veteran broadcaster to be sacked if it's proved he's "in breach of his code of conduct".
The presenter apologised for what he described as a "robust" exchange.
He tweeted: "After a robust interview with Steve Baker MP I used a very offensive word in an unguarded moment off air.
"While it was not broadcast that word in any context is beneath the standards I set myself and I apologise unreservedly.
"I have reached out to Steve Baker to say sorry."
The programmes came on an evening of turmoil in the Truss government, as Suella Braverman dramatically stepped down from her Cabinet position after admitting to sending an official document from her personal email.
In another blow to Ms Truss's embattled premiership, the ex-Cabinet minister said in a letter "it is right for me to go" and accepted responsibility for "a mistake".
It is understood the Cabinet Secretary Simon Case found two breaches of the ministerial code, including using a personal email and sending sensitive information to someone outside government.
Ms Braverman also took a departing shot at the Prime Minister and revealed she had "concerns about the direction of this government" after days of extraordinary turmoil.
Ms Braverman said: "Not only have we broken key pledges that were promised to our voters, but I have had serious concerns about this Government's commitment to honouring manifesto commitments."
The former Cabinet minister added: "Pretending we haven't made mistakes, carrying on as if everyone can't see we have made them and hoping that things will magically come right is not serious politics."
