Rishi Sunak will for the first time face a super-committee of senior MPs as they question him on the cost-of-living crisis, migration, the war in Ukraine and the state of the union.
The Prime Minister will appear before the Commons Liaison Committee of select committee chairs on Tuesday to be scrutinised on other topics including health and security.
Foreign Affairs Committee chair Alicia Kearns and her counterparts on European Security and Home Affairs, Sir Bill Cash and Dame Diana Johnson, will take part.
