Tottenham striker Richarlison faces up to a month on the sidelines after picking up a knee injury against Wolves.
It is a huge blow for player and club, with the Brazilian having scored nine goals in his previous 10 Premier League games.
Ange Postecoglou told the club’s media channels on Friday: “Going through from the last game, Richy picked up a bit of a knee injury so he's going to missing for two or three weeks.
"He's had a great middle part of the season for us and been a big contributor but that's kind of how his season has gone and we'll just have to compensate for him not being there."
Postecoglou later added in his press conference: “Richarlison's out three to four weeks, he picked up a knee injury in the last game so he's out for a while."
However, Brazil boss Dorival Junior seemingly downplayed the severity of the injury, as he confirmed Richarlison had been called up for international duty later this month.
"The Richarlison case, this morning, Dr. Rodrigo Lasmar was contacted as soon as the news broke,” Dorival said.
“They are optimistic, they discussed the situation. He will probably miss the next match of his team, but he will be fit shortly after. It's not a situation that is a problem."
In Richarlison’s absence, captain Heung-min Son will lead the line, with Dejan Kulusevski, Timo Werner and Brennan Johnson competing for the two supporting roles.
Right-back Pedro Porro is also out, having failed to shake off the knock which ruled him out of the home defeat to Wolves. Emerson Royal is expected to again deputise.
In better news, fellow full-back Destiny Udogie is fit again and in contention to start against Palace.
“Destiny has a chance for tomorrow, he trained so we’ll see how he pulls up. Pedro is probably another week away.”
Elsewhere, Ryan Sessegnon is unlikely to play again this season after undergoing surgery on his right hamstring. It is a huge blow for the young defender, who returned in January after 11 months out with an injury on his opposite hamstring.
Back-up goalkeeper Fraser Forster is sidelined for a couple of months with an ankle injury, while Manor Solomon is a week away from returning after knee surgery.
