A rampant St Kilda have spoiled Hawthorn's AFLW housewarming party, thumping the Hawks by 53 points as both teams had players go down with knee injuries.
The Hawks were playing their first home game at Box Hill City Oval but were rattled at the opening bounce when ruck Tamara Luke went down clutching her right knee and had to be helped off the ground.
The Saints set the win up with a four-goal first term and kept the Hawks goalless in three quarters in a 9.9 (63) to 1.4 (10) victory, though it was soured by Jayde Van Dyk's second-quarter knee injury.
Hawthorn's Louise Stephenson was also injured when she got her left ankle caught underneath herself in a first-quarter tackle.
Though she returned in the second quarter, the key defender was pulled from the game at halftime.
Sunday's victory marked the first time the Saints had started a season 2-0, while the Hawks sit 0-2.
Caitlin Greiser (three goals), Kate Shierlaw (two) and Jessica Matin (two) hit the scoreboard while rebounding defender Bianca Jakobsson (21 disposals, eight intercepts) was dominant.
Midfielders Tarni White (18 disposals), Olivia Vesely (17 touches) and Georgia Patrikios (16 touches) benefited from Erin McKinnon's ruck dominance in Luke's absence.
Hawthorn skipper Tilly Lucas-Rodd (20 disposals, 14 tackles) was excellent, supported by Tamara Smith, Aileen Gilroy, Kaitlyn Ashmore and No.2 draft pick Jasmine Fleming.
Shierlaw got St Kilda's day off to the perfect start from a set shot.
Two clever snaps from Matin and Greiser's first of the day kicked the Saints out to an imposing 27-point lead at quarter-time.
Van Dyk's day ended in the second quarter when her left leg buckled as her kick was smothered by Dominique Carbone, a play which started the counterattack that led to Gilroy snapping the Hawks' only goal.
The Saints restored their 27-point lead when Nat Exon put the ball out in space for Greiser, who gathered it in the pocket and brilliantly dribbled home her second goal.
Hawthorn huffed and puffed early in the third but couldn't hit the scoreboard.
Nicola Stevens' outside-of-the-boot snap and Shierlaw's second helped the Saints nudge their lead out to 39 at the final change.
St Kilda put the foot down, with majors to Greiser and Hannah Stuart adding extra padding to the final margin.
