Top-flight clubs will be asked to provide proof of four positive Coronavirus test results in order to have a Premier League match postponed.
This will take effect from the next round of league fixtures and will focus on a shift from 'available players' to 'active cases'.
Clubs gathered at a Premier League meeting to review the current system in place and there were no objections to the new policy sides will now adhere to.
Four positive cases will now serve as the minimum threshold to request a match being called off as opposed to an automatic trigger for games not going ahead as scheduled.
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This change in approach comes after the chaos caused to the fixture list within the last month, which has seen 21 matches called off as the Omicron variant left teams down to the bare bones.
Clubs have previously been permitted to submit a postponement request if they did not have 13 available players plus a goalkeeper, though there was no minimum requirement of Covid cases and injuries were also take into account.
Many believe these guidelines have been exploited by clubs in recent weeks, but steps have now being taken to stamp out any further unnecessary congestion to the schedule where possible.
Everton have seen Premier League fixtures against Leicester City (twice) and Newcastle United called off due to their opponents being unable to field a team. The Blues also had to request to postpone their trip to Burnley.
Liverpool, meanwhile, saw their Boxing Day clash at Anfield with Leeds United postponed for the same reason.
Also being scrapped is mandatory Covid pass checks on fans at stadia after clubs agreed for this to end.
Premier League sides rolled out this procedure in response to the government's move to Plan B restrictions.
But Prime Minister Boris Johnson has since confirmed a return to Plan A after falling Covid cases, meaning checks at venues holding 10,000 people or more are no longer required by law.
Commenting on their decision to update Covid-19 guidance, a Premier League statement read:
"Following a club meeting today, the Premier League's COVID-19 match postponement guidance has been updated to include a COVID-19 impact threshold.
"From now on, if a club applies to postpone a match on the grounds of insufficient players due to COVID-19, they must have a minimum of four positive cases within their squad.
"This guidance will come into effect ahead of the next Premier League fixture on Saturday 5 February (Burnley v Watford).
"Throughout the pandemic, the Premier League has adapted its guidance in response to the wider public health situation. The guidance was last updated in December in response to the emergence of the Omicron variant.
"The League's postponement rules and guidance are designed to protect the wellbeing of players and staff, while maintaining the sporting integrity of the competition and the quality of squads playing League matches.
"Club applications will continue to be assessed on a case-by-case basis. The Premier League Board examines a number of factors, including the ability of a club to field a team; the status, severity and potential impact of COVID-19; and the ability of the players to safely prepare for and play the match.
"The detail within all applications is scrutinised by the League’s specialist staff before the Board makes its decision.
"Click here to read the updated guidance on the Premier League's match postponement process.
"It was also confirmed today that the Premier League’s COVID-19 Emergency Measures will be reviewed weekly, with the aim of them expiring on 28 February at the latest.
"Measures include wearing face coverings while indoors, observing social distancing, limiting treatment time, as well as testing."
