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The Conversation
The Conversation
Prakash Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina

People produce endocannabinoids – similar to compounds found in marijuana – that are critical to many bodily functions

A healthy endocannabinoid system is critical to the human body’s immune functions. Jose Luis Pelaez Inc/Digital Vision via Getty Images

Over the past two decades, a great deal of attention has been given to marijuana – also known as pot or weed. As of early 2023, marijuana has been legalized for recreational use in 21 states and Washington, D.C., and the use of marijuana for medical purposes has grown significantly during the last 20 or so years.

But few people know that the human body naturally produces chemicals that are very similar to delta-9-tetrahydrocannabinol, or THC, the psychoactive compound in marijuana, which comes from the Cannabis sativa plant. These substances are called endocannabinoids, and they’re found across all vertebrate species.

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