The Kansas City Chiefs will host the Buffalo Bills in one of the heavyweight clashes of week six, but despite Josh Allen facing Patrick Mahomes many times before, it will be a first in both of their careers.
Mahomes will be named as a home underdog for the first time in his NFL career, with the Chiefs quarterback always heavily backed at Arrowhead Stadium. Mahomes has been favoured in his first 41 home starts, including the post-season, up until now.
This record is the longest ever streak to begin a career in the Super Bowl era, but all good things must come to an end. Allen's Bills side have been tipped as the Super Bowl favourites this year, and the visiting quarterback has been given the edge on Sunday.
