NFL World Reacts to 49ers' Christian McCaffrey's Apparent Knee Injury vs. Bills

McCaffrey left Sunday night's game vs. the Bills with a knee injury. | Gregory Fisher-Imagn Images

San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team officially dubbed a knee injury.

The 28-year-old gave himself before being touched, and immediately ran to the sideline before being taken to the locker room.

Given McCaffrey's injury history and the fact that he already missed the first eight games of the 2024 season with bilateral Achilles tendinitis, the NFL world was rightfully concerned about the news. Take a look:

McCaffrey.

That freaking sucks.
— Field Yates (@FieldYates) December 2, 2024

49ers fans seeing Christian McCaffrey get hurt against the Bills pic.twitter.com/1e2YcfgipH
— Conald Peterson (@WhyGarth) December 2, 2024

Drafting Christian McCaffrey number one, ride the struggle bus all season, get him back, only to see him pull up lame and head for the tent..... pic.twitter.com/6Cm8nrcS9C
— Robert Joyner (@robnashville) December 2, 2024

People who drafted Christian McCaffrey #1 overall (me) pic.twitter.com/qEwG4TEOXz
— ⚜️Alan Thomas⚜️ (@CardN_AL) December 2, 2024

Asking Christian mccaffrey to play in the snow fresh off an injured Achilles is wild when you think about it pic.twitter.com/gcwcJ1ba2H
— John (@iam_johnw) December 2, 2024

Christian McCaffrey has shown football fans how hard it is to play in snow.

How easy it is to slip or take a wrong step.

This sucks especially for a guy like him.
— Steven Baker (@steven_baker3) December 2, 2024

Christian McCaffrey non contact injury oh noo pic.twitter.com/zyxJom4E52
— Tedd Buddwell 🏀🏈 (@TedBuddy8) December 2, 2024

Lord,We lift up Christian McCaffrey to You in this moment of challenge and uncertainty. Lord, we ask for Your healing hand to be upon him, restoring strength and health to his injured leg.Surround Christian with encouragement and support, reminding him that even in this setback.
— huntzpicks (@huntzpickz) December 2, 2024

McCaffrey body seems to be wearing down. Being the workhorse for so long in Carolina catching up to him.
— RJones (@raging6907) December 2, 2024

Christian McCaffrey, PLEASE! pic.twitter.com/XKZpf3S8DA
— tianna ❄️ (@tiyanlaxspeaks) December 2, 2024

Praying for Christian McCaffrey…

He’s heading to the locker room with a non contact leg injury. pic.twitter.com/QsePE2kX1z
— JPAFootball (@jasrifootball) December 2, 2024

Christian McCaffrey prayer circle:

🕯 🕯
🕯 🕯
please be
🕯 okay 🕯
Christian McCaffrey
🕯 🕯
🕯 🕯
— Squid (@SquidK0) December 2, 2024

The 49ers traded for McCaffrey from the Carolina Panthers midway through the 2022 season. In 2023, he finished his first full season since 2019 and won the NFL's Offensive Player of the Year award in the process.

McCaffrey signed a two-year, $38 million contract extension with San Francisco in June, tying him to the franchise through the 2027 season. The deal made sure McCaffrey remained the highest paid running back in NFL history in terms of average annual value.