
I am pleased beyond belief that the sentence: "There is an official NASA D&D adventure that's just an Isekai anime with scientists" is verifiably true. Titled The Lost Universe, this system-agnostic adventure is free to download and most certainly worth a read.
Here's the central thrust: a dragon kidnapped a bunch of alien wizards and forced them to rip the Hubble Telescope out of our reality. Yes, really.