Munster have been given the green light by GAA's Central County to take on a South Africa XV at Pairc Ui Chaoimh on 10 November.
The Cork County Board's application was passed unanimously at a meeting of the Ard Chomhairle at Croke Park on Saturday.
It means that a capacity crowd of 45,000 are likely to watch Munster take on a touring South African side for the first time in the professional era.
READ MORE: Armagh boss Kieran McGeeney awarded black belt in martial arts
Munster Rugby CEO Ian Flanagan said in a statement: "This is a huge honour and significant milestone for Munster Rugby, one we are very proud to be associated with.
"Our thanks to the IRFU, GAA and Cork GAA for all their input, time and consideration given to reviewing this proposal and for permitting us to host our touring game against the South Africa Select XV at Páirc Uí Chaoimh on Thursday, November 10, on what will be an incredible and historic occasion.
"This is not only for our supporters and the rugby community, but also further reaching, and we understand the magnitude of being the first professional rugby team to play at the home of Cork GAA.
"While we recognise we have a fantastic facility in Thomond Park, one we are very proud of, bringing the game to a wider audience within the province has been one of our strategic objectives for many years and it is a credit to our staff for their commitment to reaching this goal."
The match will follow on the heels of South Africa taking on Ireland at the Aviva Stadium on November 5.
After taking on Munster, the Springboks will travel to Marseille to take on France.
Their second midweek game against Bristol Bears follows on 17 November, before further games with Italy and England.
READ NEXT:
Here's the price of a pint in each of Shamrock Rovers' Group F destinations
Rollercoaster opening round for Rory McIlroy at Tour Championship
Lee Westwood tears into Tiger Woods and Rory McIlroy and claims PGA 'copied' LIV
Craig Gordon hit by missile during Hearts' clash with Zurich in Europa League
Get the latest sports headlines straight to your inbox by signing up for free email alerts
