Stand-in skipper Moeen Ali came close to hitting England out of trouble at the death only to be bested by a debutant as Pakistan took control of the Twenty20 series for the first time.
The hosts were bowled out for just 145 in Lahore, Mark Wood excelling again as he took three for 20 and hit 95mph, but an England batting line-up missing the likes of Jos Buttler, Jonny Bairstow, Ben Stokes and Liam Livingstone misfired for the second game in a row.