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Benzinga

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Vandana Singh

Moderna Reports Promising Response Rates For Skin Cancer Combo Therapy In Resistant Patients

Moderna MRNA Cancer melanoma Oncology

Moderna

Moderna Inc. (NASDAQ:MRNA) announced on Sunday that its clinical, safety, and translational data from its Phase 1/2 study evaluating mRNA-4359 in combination with pembrolizumab in patients with checkpoint inhibitor-resistant/refractory (CPI-R/R) melanoma will be presented at the 2025 European Society for Medical Oncology Congress.

mRNA-4359 is an investigational immune-evasion targeted cancer antigen therapy (CAT) that encodes epitopes of two common immune escape pathways, PD-L1 and IDO1, to elicit antigen-specific T cell responses that may directly kill tumor cells and deplete tumor suppressor cells.

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Top stories on inkl right now

Okaloosa Mandatory Evacuation Covers Zones A and B as Hurricane Isaias Threatens 5- to 7-Foot Storm Surge

Okaloosa Mandatory Evacuation Covers Zones A and B as Hurricane Isaias Threatens 5- to 7-Foot Storm Surge

Okaloosa County ordered Zones A and B to evacuate as Hurricane Isaias nears. Shelter sites, special needs registration, and surge risks are explained.

Florida Drops Moral Exemption From Vaccine Rule but Still Plans to End Four School and Child Care Requirements

Florida Drops Moral Exemption From Vaccine Rule but Still Plans to End Four School and Child Care Requirements

Florida removed a proposed moral vaccine exemption but still plans to end four school shot rules. What parents should know after Thursday's hearing.

Missouri Deputy Struck Persephone Berger, 16, as Family Accuses Police of Misleading Them About Hit-And-Run

Missouri Deputy Struck Persephone Berger, 16, as Family Accuses Police of Misleading Them About Hit-And-Run

Persephone Berger, 16, died after a Missouri deputy struck her on a roadway. Her family says they were initially told it was a hit-and-run.

International Business Times UK

How to watch NASCAR at Charlotte II: Weekend schedule, start time, entry list, TV

How to watch NASCAR at Charlotte II: Weekend schedule, start time, entry list, TV

NASCAR is racing at the Charlotte Motor Speedway oval this weekend, but inclement weather from an approaching hurricane may impact on-track activity

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Democratic senator says Hegseth trying to hide costs of Iran war from US public

Democratic senator says Hegseth trying to hide costs of Iran war from US public

Chris Murphy says Pentagon blocked him from military base in Qatar and Iran strike on US embassy in Riyadh far worse than public led to believe

The Guardian - US

FBI released a 2-minute video featuring El-Sayed and a Michael Jackson beat. Then it’s deleted after experts claim it allegedly violates Hatch Act

FBI released a 2-minute video featuring El-Sayed and a Michael Jackson beat. Then it’s deleted after experts claim it allegedly violates Hatch Act

A formal complaint has been filed at the Office of Special Counsel.

We Got This Covered

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Top stories on inkl right now

Okaloosa Mandatory Evacuation Covers Zones A and B as Hurricane Isaias Threatens 5- to 7-Foot Storm Surge

Okaloosa Mandatory Evacuation Covers Zones A and B as Hurricane Isaias Threatens 5- to 7-Foot Storm Surge

Okaloosa County ordered Zones A and B to evacuate as Hurricane Isaias nears. Shelter sites, special needs registration, and surge risks are explained.

Florida Drops Moral Exemption From Vaccine Rule but Still Plans to End Four School and Child Care Requirements

Florida Drops Moral Exemption From Vaccine Rule but Still Plans to End Four School and Child Care Requirements

Florida removed a proposed moral vaccine exemption but still plans to end four school shot rules. What parents should know after Thursday's hearing.

Missouri Deputy Struck Persephone Berger, 16, as Family Accuses Police of Misleading Them About Hit-And-Run

Missouri Deputy Struck Persephone Berger, 16, as Family Accuses Police of Misleading Them About Hit-And-Run

Persephone Berger, 16, died after a Missouri deputy struck her on a roadway. Her family says they were initially told it was a hit-and-run.

International Business Times UK

How to watch NASCAR at Charlotte II: Weekend schedule, start time, entry list, TV

How to watch NASCAR at Charlotte II: Weekend schedule, start time, entry list, TV

NASCAR is racing at the Charlotte Motor Speedway oval this weekend, but inclement weather from an approaching hurricane may impact on-track activity

One subscription that gives you access to news from hundreds of sites

Already a member? Sign in here

Democratic senator says Hegseth trying to hide costs of Iran war from US public

Democratic senator says Hegseth trying to hide costs of Iran war from US public

Chris Murphy says Pentagon blocked him from military base in Qatar and Iran strike on US embassy in Riyadh far worse than public led to believe

The Guardian - US

FBI released a 2-minute video featuring El-Sayed and a Michael Jackson beat. Then it’s deleted after experts claim it allegedly violates Hatch Act

FBI released a 2-minute video featuring El-Sayed and a Michael Jackson beat. Then it’s deleted after experts claim it allegedly violates Hatch Act

A formal complaint has been filed at the Office of Special Counsel.

We Got This Covered

Our Picks

Woman finds a white purse at a thrift store. Then she unzips a small pocket and realizes it isn’t empty: ‘This is crazy’

That was a surprise!

We Got This Covered

Pop Star Britney Spears Reportedly Branded 'Clueless' by Critics Over Recent Dollywood Ride Video

Britney Spears shared footage from a family visit to Dollywood, praising the Tennessee attraction, while some online viewers criticised the language heard during a spinning-ride video.

International Business Times UK

What Happened to Travis Barker? Musician Shares Hospital Photos as Kourtney Kardashian Stays by His Side

Travis Barker says he underwent cubital tunnel release surgery after experiencing numbness in his arm, hand and fingers, adding that he hopes to resume drumming within weeks.

International Business Times UK

Woman orders a Whopper and a Whopper Jr. at a mall Burger King. Then she sees the $30 total and shows the camera the tray: ‘This is crazy’

She showed everything that came with it.

We Got This Covered

'I didn't know this place existed': Britney Spears enjoys family day at Dollywood

Britney Spears enjoyed a visit to Dollywood with her two sons - but admitted she hadn't been aware the theme park "existed" before their trip.

How Jim Bakker became the Johnny Carson of Christian TV

When I was researching my 2017 book, “PTL: The Rise and Fall of Jim and Tammy Faye Bakker’s Evangelical Empire,” I interviewed dozens of former staffers and supporters of PTL, the ministry, television and theme park empire that the Bakkers built starting in the 1970s.

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