
First reported by Engadget, MIT bioengineering researcher Lauren Ramlan broke new ground in the ongoing quest to run Doom on everything. In a paper and accompanying video for a semester project, Ramlan proposes running Doom through a 1-bit display of bioluminescent E. coli capable of displaying the game at just shy of three frames per day.
First, a quick clarification on "running" Doom—this is a project focused on displaying Doom in an absurd and nontraditional manner. Like Sam Chiet's Doom in Microsoft Notepad, you'd still need a more traditional computer to output the Doom itself, it's not those E. coli making the calculations.