Marc Skinner has admitted the WSL Manchester derby is a "huge moment" for his United team.
The Red Devils are second in the standings but could return to the summit if Chelsea slip up against Arsenal and United beat City later on Sunday. That would give them a huge chance of winning the league for the first time, with only one game remaining after this weekend.
But to win the derby, against a City side still hopeful of a top three finish themselves, they will have to bounce back quickly from the blow of losing a cup final. United were beaten by Chelsea at Wembley last weekend after Sam Kerr struck the games only goal, despite Skinners' team controlling the game for long periods.