Harry Maguire could return to the Manchester United side against Brighton after recovering from a knee injury but Marcus Rashford is out with bronchitis.
Maguire missed the last two games against Chelsea and Brentford with a knee problem but will be included in the travelling squad for United's penultimate game of the season.
Rashford has been ruled out and reserve centre-back Eric Bailly could also be unavailable due to a back problem. Luke Shaw has resumed individual training but is still not expected to play again this season.