Raphael Varane will not play again for Manchester United before the World Cup starts next month.
Varane was forced off with a hamstring injury against Chelsea on Saturday and will be unavailable for the upcoming games against FC Sheriff, West Ham, Real Sociedad, Aston Villa in the Premier League and the League Cup, and Fulham.
Victor Lindelof is likely to partner Lisandro Martinez against Sheriff but Harry Maguire could return to the United squad for the first time in six weeks after recovering from a thigh strain.