Kieran Trippier and Callum Wilson had to settle for bench roles at the Etihad Stadium as Eddie Howe had a close to full strength squad to choose from against the champions.
The Magpies also left Fabian Schar on the bench after the Swiss star had suffered a knock last weekend. Howe was also unable to name Jonjo Shelvey in his starting line-up with Sean Longstaff getting his chance.
United started with Martin Dubravka in goal with Emil Krafth and Matt Targett full-backs while Lascelles and Dan Burn were in the heart of defence. Joelinton, Longstaff and Bruno Guimaraes patrolled the midfield.
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Howe did not punish Allan Saint-Maximin by axing him at City despite a social media backlash over an interview with a French magazine. Saint-Maximin, Chris Wood and Miguel Almiron were in the frontline for the Magpies. Howe also named Paul Dummett on the bench.
You can follow the game as it happens in our live match blog here, with all the post-match reaction and analysis.
Today's line-ups
Newcastle: Dubravka, Krafth, Lascelles, Burn, Targett Bruno Guimaraes, Longstaff, Joelinton, Almiron, Wood Saint-Maximin.
Subs: Dummett, Schar, Wilson, Ritchie, Trippier Manquillo, Murphy, Darlow, Gayle.
Man City: Ederson, Joao Cancelo, Dias, Laporte, Zinchenko De Bruyne, Rodri, Gundogan, Sterling, Gabriel Jesus, Grealish.
Subs: Ake, Steffen, Bernardo Silva, Fernandinho, Mahrez, Foden Egan-Riley, Mbete-Tabu, Palmer.
Referee: Stuart Attwell (Warwickshire)
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