Ruben Dias and Nathan Ake will not feature for Manchester City against Manchester United after both failed to recover from the injuries they picked up in midweek.
The two central defenders started together in the FA Cup win over Peterborough but neither emerged for the second half. Ake suffered an issue while jumping for a challenge while Dias felt something in his hamstring.
After assessment of the problems, City's medical staff confirmed to Pep Guardiola as early as Friday lunchtime that they would be unable to face United on Sunday. Dias will be out for between four and six weeks with a hamstring injury, although the manager hopes Ake will be back sooner.