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The Guardian - UK
The Guardian - UK
Science
Andrew Gregory Health editor

Lupus patients in England in remission after pioneering NHS trial of GM therapy

A healthcare worker in blue gloves inserts an IV line into a patient's arm while colleagues observe in a hospital room
Katie Tinkler was one of the patients whose severe lupus went into remission after NHS trial of CAR T-cell therapy at University College London hospital. Photograph: Lucy North/PA

Five lupus patients in England are in remission after being treated with a revolutionary therapy that genetically modifies their own cells, in a medical breakthrough that could offer people a cure, doctors have said.

CAR (chimeric antigen receptor) T-cell therapy involves removing a type of white blood cell also called T lymphocytes, which are crucial for hunting out infected or damaged cells, and engineering them to spot and destroy disease. The T-cells are then fed back into the patient via an infusion to reset their immune system.

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