Louis Rees-Zammit will start at full-back in Wales’ Autumn Nations Series clash with Argentina on Saturday.
He switches from the wing to fill a problem position for Wales, with Liam Williams and Leigh Halfpenny both injured.
Rees-Zammit made his Test debut after going on as a second-half substitute for Halfpenny against France in 2020, but the Gloucester speedster’s subsequent 19 appearances were all on the wing.
Alex Cuthbert, who has recovered from a shoulder issue, completes the back three alongside Rio Dyer, a try-scorer on his Test debut against New Zealand last weekend.
Gareth Anscombe, who deputised for Halfpenny five days ago, reverts to fly-half, replacing Rhys Priestland.
Elsewhere, prop Dillon Lewis starts instead of Tomas Francis and experienced Ospreys flanker Dan Lydiate features in the back-row.
With Leicester flanker Tommy Reffell sidelined because of a rib injury, captain Justin Tipuric moves across to openside, packing down with number eight Taulupe Faletau in a back-row trio boasting 246 caps.
There is no place in the matchday 23 for Wales’ record cap holder Alun Wyn Jones, as Ben Carter provides second-row cover, with other bench changes seeing props Rhodri Jones and Sam Wainwright selected, plus Priestland and Ospreys flanker Jac Morgan.
