Lorraine Kelly says the women who age the best haven't have cosmetic work done, or the bare minimum.
The weekday TV presenter, 63, warns that people "don't recognise" themselves after going under the knife to maintain their appearance.
The Lorraine presenter, also spoke of how it feels like a fabulous time to be her age, as the mum-of-one continues to entertain the nation with her interviews on ITV.
Lorraine has previously said she is avoiding nips and tucks as she doesn't want to look like a "boiled egg" and has opted to embrace her natural looks, adding "the way my face is supposed to be".
The TV presenter, who is this month's Prima cover star, told the magazine: “I think the women who age the best are the ones who haven’t had work done – or only the bare minimum.
Having surgery is like jazzing up your living room: you start by getting new curtains, then the carpet looks shabby, so you change that, and then the sofa doesn’t fit. Soon enough, you don’t recognise yourself any more.”
In December Lorraine said: "I don't mind that I've got wrinkles, or that I have signs of ageing, because it's the way my face is supposed to be.
"Of course, I want to look as good as I can but I don't want to look like a boiled egg and as though I have no features!"
The TV star spoke about Madonna, as she praised her career but said she no longer looks "natural".
She added to Closer magazine: "God love Madonna, the things she's done for the LGBT community are fantastic, she's a smasher and I love her music. But, you can't see her features anymore, it makes no sense to me, she used to look so natural."
She added that if someone gets botox and it boosts their confidence then that's great, but advised people to do their homework.
Madonna, 64, has consistently revamped her image over her 40-year long career. But, recent Instagram photos of the Like A Virgin singer have caused a stir with many asking if she has gone under the knife.
The singer hasn't discussed if she has had surgery but said in 2012: "I am certainly not against plastic surgery.
"However, I am absolutely against having to discuss it."
Lorraine, who has presented her self-titled show since 2010 admits she can get imposter syndrome, but then, remembers the wise words of Billy Connolly, who says you have to move past that feeling.
The star has previously spoken of how she grapples with imposter syndrome, telling OK! magazine: "All the time, I'm from a very working class background. I remember sitting in a hotel and talking to Oprah Winfrey and thinking, "Seriously?! This is just insane."
Read the full interview in Prima’s May issue, on sale 29th March. It is available in all supermarkets and online at MagsDirect.