It would have needed more than the Hand of God to save Liverpool at the Stadio Diego Armando Maradona.
The Reds were woeful as a sharper, slicker Napoli side exposed the flaws in their changed system to earn a deserved Champions League victory that could have been by more.
Piotr Zielinski opened the scoring with a penalty after a James Milner handball, Alisson then saved a second spot-kick from Victor Osimhen, Frank Zambo Anguissa fired in a slick second and Giovanni Simeone tapped in a third.