The number of American children filling a leucovorin prescription rose roughly sevenfold over the course of 2025, and a sharp single-week jump coincided with a federal press conference promoting the drug for autism, according to an analysis published this month in The New England Journal of Medicine.
The research, led by Kao-Ping Chua of the University of Michigan, drew on the IQVIA Longitudinal Prescription Database, which captures about 93 percent of prescriptions filled at United States retail pharmacies. Across 2025, the database recorded 150,026 leucovorin prescriptions dispensed to 47,394 children.
