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Jess Root

Kyler Murray vs. Patrick Mahomes in Week 1 at State Farm Stadium

Patrick Mahomes Kyler Murray Cardinals DeAndre Hopkins Chiefs Kliff Kingsbury Arizona

The Arizona Cardinals announced their home opener ahead of the official 2022 NFL schedule release. They will start the season at home with a big interconference game.

They will play at home in Week 1 and face quarterback Patrick Mahomes and the Kansas City Chiefs Sunday Sept. 11 at 4:25 p.m. ET (1:25 p.m. Arizona time).

The Cardinals will be without receiver DeAndre Hopkins as that will be the start of his six-game suspension for PED use.

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