Kevin De Bruyne taunted Manchester United after their derby mauling by claiming they lacked the stamina to compete with Pep Guardiola's side.
Man City secured an emphatic 4-1 win, with De Bruyne scoring twice and setting up another as the Blues took a huge step towards retaining the title, opening up a six-point lead over Liverpool, who have a game in hand.
Interim United boss Ralf Rangnick has tried to implement a high-pressing style since taking charge, similar to Guardiola at City and Liverpool under Jurgen Klopp.