Jordan Larmour is out for the remainder of the Six Nations with a hip injury as Munster's Jeremy Loughman is called up to the Ireland squad for the first time.
Larmour, who hasn't featured in the championship to date and last played for Ireland in the summer series against Japan, suffered the injury in Leinster's victory over Benetton on Saturday.
Loosehead Loughman is added after Andrew Porter was last week ruled out of the final two rounds against England at Twickenham on Saturday and Scotland at the Aviva Stadium seven days later.