James Wade became the first seed to crash out of the World Championship after losing to world number 57 Matt Campbell.
The Canadian produced the biggest win of his career as he came from 2-1 down to beat the four-time semi-finalist 3-2.
Wade, seeded 13th, was in good form, having reached a final, semi-final and quarter-final in the last three major tournaments, but is out of the main event of the year before Christmas.
Keegan Brown will not want to hear the name Boris Krcmar again after enduring a chastening afternoon.
Brown was left confused when MC John McDonald mistakenly called out his opponent’s name when he was due to walk onto the Alexandra Palace stage before the first-round match.
Things got even worse once play began as the Croatian cruised to a 3-1 win.
Brown took the first set but things went downhill from there, with Krcmar coming back to reach the second round for the second successive year, with Dirk van Duijvenbode waiting for him in the next round.
Elsewhere in the afternoon session, Jeffrey de Graaf produced a comeback to beat Ritchie Edhouse 3-2 while Tomoya Goto beat Ian White 3-1.