Ireland's leaders still standing in Rome have been given the demand to step up and be counted - after the loss of another experienced star on the eve of today's Italy clash.
Leinster centre Garry Ringrose is the latest casualty - the 28-year-old misses out after a calf issue that he picked up last night tightened up on the trip to the Italian capital on Thursday.
Stuart McCloskey is recalled to the side and will partner Bundee Aki in the absence of Ringrose, with Jimmy O'Brien set for his debut Six Nations appearance off the bench - as is Jack Crowley, who provides out-half cover.
