International tourists are scheduled to arrive at Sydney airport almost two years after Australia closed its borders to combat the spread of what was then a new and confounding virus.
The first plane loads of vaccinated travellers will come from the US, Japan and Canada early on Monday, in welcome news to hospitality and tourism operators.
The reopening marks a significant milestone for Australia's COVID-19 recovery plans, with past arrivals largely restricted to citizens, permanent residents and, more recently, international students.
"We are going from COVID cautious to COVID confident when it comes to travel," Prime Minister Scott Morrison declared on Sunday.
Australian authorities have defended the prolonged border restrictions, which have been among the world's strictest, for helping stem the spread of the virus, leading to low death rates by global standards.
"COVID has seen Australia retreat from the world. The national mood has become more insular," Tim Soutphommasane, a professor of sociology and political theory at Sydney University, told AAP.
"To have Australia welcome international tourists again marks something of a re-engagement with the world."
Tourism Australia is spending $40 million on a campaign to entice international tourists Down Under. In early 2020, the government agency suspended a Kylie Minogue-led advertising campaign amid the devastation of the bushfires and the initial stages of the pandemic.
Peter Shelley, managing director of the Australian Tourism Export Council, says it will take time to rebuild the sector.
"We were the first industry to fully close and will be the last industry to fully reopen and most of our businesses don't expect to see any significant income from the inbound market until well into next year," he said.
"While businesses will be relieved, they also know the challenge lays ahead in rebuilding from the ground up."
Around 9.5 million international visitors came to Australia in 2019 before border closures brought the travel industry to a standstill, Tourism Australia data shows.
Australia draws the majority of its visitors from China, New Zealand, South Korea, Japan, Singapore, the UK and US.