A landmark clinical trial supported by the National Institutes of Health and published on June 15, 2026, in the Journal of the American Medical Association has found that adults with prediabetes who participated in an intensive lifestyle intervention had a 25% lower risk of developing three or more serious chronic conditions over more than 20 years of follow-up — a finding that provides the most durable evidence to date that lifestyle change is not merely a wellness strategy but a powerful medical prevention tool.
The study arrives at a moment when approximately 96 million American adults — more than one in three — are living with prediabetes, and when chronic disease multimorbidity has become one of the costliest and most debilitating health challenges in the United States.
