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Simon Kolstoe, Reader in Bioethics, University of Portsmouth

Human challenge studies: what we've learned from intentionally infecting people with COVID

neative/Shutterstock

When COVID began to spread rapidly in 2020, sending the UK and other countries into lockdowns, many people asked what they could do to help. While millions of people found novel ways to help others in their communities, a large number became interested in volunteering for medical research.

This presented an interesting situation for researchers who normally struggle to recruit participants. Suddenly there was significant enthusiasm from the public to volunteer for research studies. This included a willingness to volunteer for potentially risky “human challenge trials” that would intentionally expose participants to SARS-CoV-2, the virus that causes COVID.

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