Manchester City travel to Madrid to try and finish off the tie they currently lead 4-3 on aggregate.
Guardiola's men dominated the first leg but were given several reminders of Real Madrid's quality on the night, with forward Karim Benzema in rare form.
While a draw would be enough to see the Citizens qualify for their second Champions League final in as many seasons, a victory for City would make them only the third side in history to beat Real Madrid in four successive matches. Ajax were the first to do so, with their victories spanning several decades between 1973 and 1995. Bayern Munich also did so in a shorter timeframe between 2000 and 2002.