Miami entered its Week 8 game, a Friday night showdown with Louisville, locked in as one of the top teams in the country. It left it with its quarterback plummeting down Heisman odds lists, and with a serious dent to its postseason aspirations after a 24–21 loss.
The Cardinals jumped out to a 14–0 lead over the Hurricanes, with Miller Moss rushing for one touchdown and throwing for another. Miami would cut the lead to 14–10 by halftime. After trading field goals in the third quarter, Louisville found the end zone to open fourth quarter scoring. The Cardinals looked like they might put the game away after picking off Carson Beck for a third time on the ensuin possession, but Isaac Brown fumbled the ball away on the next play, setting up a 12-yard touchdown run for Miami receiver Malachi Toney, cutting Louisville's lead to 24–21.
